Description
Product Characteristics:
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Subcellular location: Secreted, Cell membrane
Synonyms: TOSO, FAIM3, Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso
Target Information: Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]\, Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]